Laboratory of Retroviruses, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
J Virol. 2013 Aug;87(15):8792-7. doi: 10.1128/JVI.03555-12. Epub 2013 May 22.
The full-length sequence of simian foamy virus serotype 2 (SFVmcy-2), isolated from a Taiwanese macaque, was determined. SFVmcy-2 was highly related to SFV serotype 1 (SFVmcy-1), an isolate from the same species, except in the putative receptor binding domain (RBD) in env, which contained novel sequences related to SFV serotype 3 (SFVagm-3), isolated from an African green monkey. The results identify a potential region of neutralization in SFVs and demonstrate recombination between genetically divergent foamy viruses.
从台湾猕猴中分离到的猴泡沫病毒血清型 2(SFVmcy-2)全长序列已被确定。SFVmcy-2 与同一种属的 SFV 血清型 1(SFVmcy-1)高度相关,除了 env 中假定的受体结合域(RBD),它包含与从非洲绿猴中分离到的 SFV 血清型 3(SFVagm-3)相关的新序列。结果鉴定了 SFV 中的一个潜在中和区域,并证明了遗传上不同的泡沫病毒之间的重组。