快照：染色质对病毒感染的控制。
Snapshots: chromatin control of viral infection.
机构信息
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
出版信息
Virology. 2013 Jan 5;435(1):141-56. doi: 10.1016/j.virol.2012.09.023.
Abstract
Like their cellular host counterparts, many invading viral pathogens must contend with, modulate, and utilize the host cell's chromatin machinery to promote efficient lytic infection or control persistent-latent states. While not intended to be comprehensive, this review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment. Contributions focus on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, viral interactions with cellular chromatin modulation machinery, and control of viral latency-reactivation cycles.
摘要
与它们的细胞宿主类似，许多入侵的病毒病原体必须应对、调节和利用宿主细胞的染色质机制，以促进有效的裂解感染或控制持续潜伏状态。虽然这并不是全面的，但本文综述代表了病毒与染色质环境动态相互作用的概念快照的汇编。贡献集中在感染过程中的染色质动态、病毒规避细胞染色质抑制、大型 DNA 病毒的染色质组织、固定和持续存在、病毒与细胞染色质调节机制的相互作用以及病毒潜伏期-激活周期的控制。
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