Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA.
Viruses. 2013 May 23;5(5):1346-73. doi: 10.3390/v5051346.
Kaposi's sarcoma-associated herpesvirus is an oncogenic γ-herpesvirus that causes latent infection in humans. In cells, the viral genome adopts a highly organized chromatin structure, which is controlled by a wide variety of cellular and viral chromatin regulatory factors. In the past few years, interrogation of the chromatinized KSHV genome by whole genome-analyzing tools revealed that the complex chromatin landscape spanning the viral genome in infected cells has important regulatory roles during the viral life cycle. This review summarizes the most recent findings regarding the role of histone modifications, histone modifying enzymes, DNA methylation, microRNAs, non-coding RNAs and the nuclear organization of the KSHV epigenome in the regulation of latent and lytic viral gene expression programs as well as their connection to KSHV-associated pathogenesis.
卡波济肉瘤相关疱疹病毒是一种致瘤性γ疱疹病毒，可导致人类潜伏感染。在细胞中，病毒基因组采用高度组织化的染色质结构，由多种细胞和病毒染色质调节因子控制。在过去的几年中，通过全基因组分析工具对染色质化的 KSHV 基因组进行检测，揭示了在受感染细胞中跨越病毒基因组的复杂染色质景观在病毒生命周期中具有重要的调节作用。本综述总结了关于组蛋白修饰、组蛋白修饰酶、DNA 甲基化、microRNAs、非编码 RNA 和 KSHV 表观基因组的核组织在调节潜伏和裂解病毒基因表达程序中的最新发现，以及它们与 KSHV 相关发病机制的联系。
