Department of Oncological Clinical Pathology, Flow Cytometry Lap, South Egypt Cancer Institute, Assiut University, Egypt.
Department of Pediatrics, Faculty of Medicine, Assiut University, Egypt
Clin Appl Thromb Hemost. 2015 Jan;21(1):58-65. doi: 10.1177/1076029613489595. Epub 2013 May 22.
We studied the level of lipid peroxide, nitric oxide (NO), trace elements (TEs), and microparticles (MPs) in Gaucher disease (GD) before and after 1 year of enzyme replacement therapy (ERT). A total of 15 children with GD and 15 healthy controls were enrolled in this study. Serum level of lipid peroxide, NO, and TEs was determined. The MPs were detected by flow cytometry. The level of lipid peroxide was significantly higher in the patients than in the controls even after ERT. Although NO level was normalized in the patients after ERT, zinc and copper were still lower in the patients after ERT. The percentages of various MPs were significantly higher in the patients than in the controls both before and after ERT. There were positive correlations between chitotriosidase and both lipid peroxide and total MPs.
The GD is associated with alteration in oxidant and antioxidant status and high level of circulating MPs.
我们研究了戈谢氏病（GD）患者在酶替代治疗（ERT）前后脂质过氧化物、一氧化氮（NO）、微量元素（TEs）和微颗粒（MPs）的水平。本研究共纳入 15 名 GD 患儿和 15 名健康对照者。测定血清脂质过氧化物、NO 和 TEs 水平，用流式细胞术检测 MPs。ERT 后患者的脂质过氧化物水平仍显著高于对照组。尽管 ERT 后患者的 NO 水平正常化，但 ERT 后患者的锌和铜仍较低。ERT 前后患者各种 MPs 的百分比均显著高于对照组。几丁质酶与脂质过氧化物和总 MPs 均呈正相关。
戈谢氏病与氧化应激和抗氧化状态改变以及循环 MPs 水平升高有关。
