Ignatov Iu D, Zaĭtsev A A, Strashnov V I, Dzhaberi M, Khnykina V I
Farmakol Toksikol. 1990 Mar-Apr;53(2):17-20.
Clonidine and its Soviet-made analogue clopheline (10 micrograms) after epidural administration to rats equally inhibited nociceptive reactions and changes in arterial blood pressure in the somatic and visceral pain tests. In patients with obliterating atherosclerosis of the lower extremities clopheline (100 and 200 micrograms) relieved the pain syndrome and shifts of II-hydroxycorticosteroids in blood, induced bradycardia and the background arterial blood pressure-dependent antihypertensive effect.
可乐定及其苏联产类似物氯苯乙胍（10微克）硬膜外注射给大鼠后，在躯体和内脏疼痛试验中同等程度地抑制伤害性反应和动脉血压变化。在下肢闭塞性动脉粥样硬化患者中，氯苯乙胍（100和200微克）缓解了疼痛综合征和血液中11-羟基皮质类固醇的变化，诱发了心动过缓和依赖于基础动脉血压的降压作用。
