Siah 泛素连接酶的调节剂和效应物。
Regulators and effectors of Siah ubiquitin ligases.
机构信息
Signal Transduction Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
出版信息
Cell Biochem Biophys. 2013 Sep;67(1):15-24. doi: 10.1007/s12013-013-9636-2.
Abstract
The Siah ubiquitin ligases are members of the RING finger E3 ligases. The Siah E3s are conserved from fly to mammals. Primarily implicated in cellular stress responses, Siah ligases play a key role in hypoxia, through the regulation of HIF-1α transcription stability and activity. Concomitantly, physiological conditions associated with varying oxygen tension often highlight the importance of Siah, as seen in cancer and neurodegenerative disorders. Notably, recent studies also point to the role of these ligases in fundamental processes including DNA damage response, cellular organization and polarity. This review summarizes the current understanding of upstream regulators and downstream effectors of Siah.
摘要
Siah 泛素连接酶是 RING 指 E3 连接酶家族的成员。Siah E3s 从果蝇到哺乳动物都保守存在。Siah 连接酶主要参与细胞应激反应，通过调节 HIF-1α 转录稳定性和活性在缺氧中发挥关键作用。同时，与氧张力变化相关的生理条件经常突出 Siah 的重要性，如在癌症和神经退行性疾病中所见。值得注意的是，最近的研究也指出这些连接酶在包括 DNA 损伤反应、细胞组织和极性等基本过程中的作用。本综述总结了 Siah 的上游调节因子和下游效应物的最新认识。
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