The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking University and National Center for Nanoscience and Technology, Beijing, China.
J Mol Med (Berl). 2013 Aug;91(8):929-38. doi: 10.1007/s00109-013-1056-7. Epub 2013 May 23.
Glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells is critical to the maintenance of blood glucose homeostasis in animals. Both decrease in pancreatic beta-cell mass and defects in beta-cell function contribute to the onset of diabetes, although the underlying mechanisms remain largely unknown. Molecular imaging techniques can help beta-cell study in a number of ways. High-resolution fluorescence imaging techniques provide novel insights into the fundamental mechanisms underlying GSIS in isolated beta-cells or in situ in pancreatic islets, and dynamic changes of beta-cell mass and function can be noninvasively monitored in vivo by imaging techniques such as positron emission tomography and single-photon emission computed tomography. All these techniques will contribute to the better understanding of the progression of diabetes and the search for the optimized therapeutic measures that reverse deficits in beta-cell mass and function.
胰岛β细胞的葡萄糖刺激胰岛素分泌（GSIS）对于维持动物血糖稳态至关重要。虽然其潜在机制在很大程度上尚不清楚，但胰岛β细胞数量的减少和β细胞功能缺陷都会导致糖尿病的发生。分子影像学技术可以在多个方面帮助胰岛β细胞的研究。高分辨率荧光成像技术为深入了解分离的胰岛β细胞或胰腺胰岛中 GSIS 的基本机制提供了新的见解，通过正电子发射断层扫描和单光子发射计算机断层扫描等成像技术可以非侵入性地监测活体β细胞质量和功能的动态变化。所有这些技术都将有助于更好地了解糖尿病的进展，并寻找优化的治疗措施来逆转β细胞数量和功能的不足。
