人类αB-晶状体蛋白（CRYA2）基因定位于11号染色体q12-q23区域。
Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23.
作者信息
Brakenhoff R H, Guerts van Kessel A H, Oldenburg M, Wijnen J T, Bloemendal H, Meera Khan P, Schoenmakers J G
机构信息
Department of Molecular Biology and Cell Biology, University of Nijmegen, The Netherlands.
出版信息
Hum Genet. 1990 Jul;85(2):237-40. doi: 10.1007/BF00193203.
The alpha B-crystallin gene (CRYA2) encodes the abundant lens protein alpha B-crystallin. A panel of human/rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster alpha B-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.
αB-晶状体蛋白基因（CRYA2）编码丰富的晶状体蛋白αB-晶状体蛋白。一组源自五种不同亲本组合的人/啮齿动物杂交细胞系，就人类染色体含量和已确立的人类染色体特异性标志物的存在情况进行了表征。使用仓鼠αB-晶状体蛋白基因的第三个外显子作为探针，对该细胞系进行CRYA2存在情况的筛选。CRYA2与各条人类染色体的分离模式显示，CRYA2与11号染色体之间的一致性程度最高。利用含有易位和/或部分缺失人类染色体的细胞杂交体，将CRYA2基因定位到11q12 - 11q23。
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