用甲氧苄啶改进脆性位点检测。
Improved fragile site detection with trimethoprim.
作者信息
McLean D A, Faed M J
机构信息
Department of Pathology, University of Dundee, Ninewells Hospital, UK.
出版信息
Hum Genet. 1990 Jul;85(2):241-3. doi: 10.1007/BF00193204.
PMID:2370056
Abstract
The effect of trimethoprim, an inhibitor of dihydrofolate reductase, in demonstrating the presence of fragile sites on human chromosomes was investigated. Lymphocyte cultures with 20 mg/l trimethoprim added at the onset of incubation gave consistently higher frequencies of fragile sites than the other culture regimes tested.
摘要
研究了二氢叶酸还原酶抑制剂甲氧苄啶在显示人类染色体上脆性位点存在方面的作用。在培养开始时添加20毫克/升甲氧苄啶的淋巴细胞培养物中，脆性位点的频率始终高于所测试的其他培养方案。
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