Dahiya R, Sharma A, Ahlawat R S
Department of Medicine, University of California, San Francisco.
Indian J Med Res. 1990 Apr;92:115-9.
Experiments were conducted to study the effects of high density lipoprotein (HDL) and apolipoproteins C, E, and A on lipoprotein lipase activity in rhesus monkeys. The lipoprotein lipase activity was inhibited up to 32 +/- 6 per cent by monkey HDL. This inhibition was considerably decreased (2 +/- 0.02%) by using apolipoprotein-poor HDL. Apolipoproteins C and E inhibited the hydrolysis of activated intralipid by monkey lipoprotein lipase to a maximum of 83 +/- 7 and 57 +/- 5 per cent respectively. Apolipoprotein A produced little inhibition of lipoprotein lipase activity. The results of these studies demonstrate that HDL and apolipoproteins compete with the substrate for the binding to lipoprotein lipase in rhesus monkeys.
进行实验以研究高密度脂蛋白（HDL）以及载脂蛋白C、E和A对恒河猴脂蛋白脂肪酶活性的影响。恒河猴HDL可将脂蛋白脂肪酶活性抑制高达32±6%。使用载脂蛋白含量低的HDL时，这种抑制作用显著降低（2±0.02%）。载脂蛋白C和E分别将恒河猴脂蛋白脂肪酶对活化乳糜微粒的水解抑制至最大程度，即83±7%和57±5%。载脂蛋白A对脂蛋白脂肪酶活性的抑制作用很小。这些研究结果表明，在恒河猴中，HDL和载脂蛋白与底物竞争结合脂蛋白脂肪酶。
