Elser J M, Woody R C
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
Headache. 1990 May;30(6):366-8. doi: 10.1111/j.1526-4610.1990.hed3006366.x.
Migraine is a common clinical diagnosis, occurring in 4-10% of school age children. Migraine in the infant and preschool child has been infrequently described in retrospective studies. We report the prospective evaluation and therapy of six children (5-42 months) with migraine. In four of the children, Prensky's criteria were used for diagnosis, while the two youngest children presented with ophthalmoplegic migraine. All children had a strong family history of migraine and presented with headache and prominent features including facial pallor, irritability, sleep disturbance or mood changes. The oldest four children were successfully treated with either amitriptyline or imipramine in low doses. The infants with ophthalmoplegic migraine failed to completely respond to any therapy. At followup 2 to 18 months later, all children were well and without toxicity. The pediatrician should be aware that migraine may begin in infancy and can be effectively and safely treated.
偏头痛是一种常见的临床诊断疾病，在学龄儿童中发病率为4% - 10%。婴幼儿和学龄前儿童偏头痛在回顾性研究中鲜有描述。我们报告了6名（5 - 42个月）偏头痛儿童的前瞻性评估及治疗情况。其中4名儿童依据普伦斯基标准进行诊断，而最年幼的两名儿童表现为眼肌麻痹性偏头痛。所有儿童均有偏头痛家族史，且均出现头痛及显著特征，包括面色苍白、易激惹、睡眠障碍或情绪变化。年龄较大的4名儿童用低剂量阿米替林或丙咪嗪成功治愈。眼肌麻痹性偏头痛婴儿对任何治疗均未完全起效。在2至18个月后的随访中，所有儿童情况良好且无毒性反应。儿科医生应意识到偏头痛可能始于婴儿期，且可得到有效且安全的治疗。
