Department of Internal Medicine and Nephrology .
Clin Exp Hypertens. 2014;36(1):52-7. doi: 10.3109/10641963.2013.783054. Epub 2013 May 23.
In this study, we aimed to investigate the relationship between vitamin D, parathyroid hormone (PTH) and cardiovascular risk (CVR) in hypertensive patients aged 65 years and over.
This study was performed with 84 hypertensive patients and 68 normotensive control group in Afyon Kocatepe University Faculty of Medicine Hospital. The determined cardiovascular risk degrees and the stages of blood pressure were compared with the levels of 25-(OH) vitamin D and PTH.
Mean systolic and diastolic blood pressure (BP) levels of the patients with vitamin D deficiency (VDD) were significantly higher than those without VDD (p<0.001 for both). Mean systolic and diastolic BP levels of the patients with hyperparathyroidism were significantly higher than those without hyperparathyroidism (p=0.012, p=0.036, respectively). CVR was reversely correlated with vitamin D but the correlation with hyperparathyroidism did not reach statistically significant level (r=-0.752, p<0.001) and (r=0.210, p=0.055), respectively.
These results indicate that the presence of hypertension is associated with VDD, as well as the stage of hypertension contributes to insufficiency, hyperparathyroidism and increased CVR. Clinicians should be aware and perhaps more aggressive for the treatment of HT and VDD in patients over 65 years of age.
本研究旨在探讨 65 岁及以上高血压患者维生素 D、甲状旁腺激素（PTH）与心血管风险（CVR）的关系。
本研究在阿菲永卡赫拉特大学医学院附属医院进行，共纳入 84 例高血压患者和 68 例血压正常的对照组。比较了确定的心血管风险程度和血压阶段与 25-（OH）维生素 D 和 PTH 水平之间的关系。
维生素 D 缺乏（VDD）患者的平均收缩压和舒张压（BP）水平明显高于无 VDD 患者（均 p<0.001）。甲状旁腺功能亢进症患者的平均收缩压和舒张压明显高于无甲状旁腺功能亢进症患者（分别为 p=0.012，p=0.036）。CVR 与维生素 D 呈负相关，但与甲状旁腺功能亢进症的相关性未达到统计学显著水平（r=-0.752，p<0.001）和（r=0.210，p=0.055）。
这些结果表明，高血压的存在与 VDD 有关，高血压的阶段也与不足、甲状旁腺功能亢进症和 CVR 增加有关。临床医生应该意识到这一点，并且可能对 65 岁以上患者的 HT 和 VDD 进行更积极的治疗。
