Zalewska Anna, Knaś Małgorzata, Gińdzieńska-Sieśkiewicz Ewa, Waszkiewicz Napoleon, Klimiuk Anna, Litwin Katarzyna, Sierakowski Stanisław, Waszkiel Danuta
Department of Pedodontics, Medical University, Bialystok, Poland.
J Oral Pathol Med. 2014 Jan;43(1):61-8. doi: 10.1111/jop.12084. Epub 2013 May 22.
In spite of relatively large amount of evidence that oxidative stress is implicated in the pathogenesis of systemic sclerosis, there is no study analyzing antioxidants profile of the saliva of these patients. The aim of this study was to compare salivary antioxidants in subjects with systemic sclerosis and the healthy controls.
The unstimulated and stimulated salivary flow and the specific activity of peroxidase, superoxide dismutase 1, the total amount of uric acid, and total antioxidant status were determined in two subgroups of systemic sclerosis women and healthy controls.
A significant increase in the specific activity of peroxidase, a significant decrease in the total amount of uric acid and total antioxidants status in unstimulated saliva as well as a significant increase in all antioxidants examined in stimulated saliva of group with normal salivary flow rate as compared to the healthy controls were observed. Our results showed a significant decrease in the specific activity of peroxidase in unstimulated and a significant decrease in all antioxidants examined in stimulated saliva of the group with hyposalivation as compared to the group with normal salivary flow rate.
Our results prove that impairment of the salivary glands in the course of systemic sclerosis may be attributed to free radicals, and it is correlated with disease duration.
尽管有相对大量的证据表明氧化应激与系统性硬化症的发病机制有关，但尚无研究分析这些患者唾液中的抗氧化剂谱。本研究的目的是比较系统性硬化症患者和健康对照者唾液中的抗氧化剂。
在系统性硬化症女性和健康对照的两个亚组中，测定了非刺激性和刺激性唾液流量、过氧化物酶、超氧化物歧化酶1的比活性、尿酸总量和总抗氧化状态。
与健康对照相比，观察到非刺激性唾液中过氧化物酶比活性显著增加、尿酸总量和总抗氧化状态显著降低，以及唾液流速正常组的刺激性唾液中所有检测的抗氧化剂显著增加。我们的结果显示，与唾液流速正常组相比，唾液分泌减少组的非刺激性唾液中过氧化物酶比活性显著降低，刺激性唾液中所有检测的抗氧化剂显著降低。
我们的结果证明，系统性硬化症病程中唾液腺的损伤可能归因于自由基，并且与疾病持续时间相关。
