Pediatric Pulmonary Unit, Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel.
J Oral Pathol Med. 2010 Jan;39(1):16-21. doi: 10.1111/j.1600-0714.2009.00813.x. Epub 2009 Jul 27.
Cystic fibrosis (CF) is characterized by altered exocrine secretions; however, no comprehensive compositional profile of CF serous and mucous saliva secretions has been published.
We analyzed salivary flow rate and composition, and oxidative stress-related parameters, comparing CF patients with non-CF bronchiectasis patients and the healthy controls.
Median salivary magnesium concentration and lactate dehydrogenase activity were significantly lower in CF patients than in the healthy controls. Salivary total protein concentration was 45% higher in CF patients than in non-CF bronchiectasis patients. CF patients showed 8% lower levels of peroxidase compared with non-CF bronchiectasis. Salivary total antioxidant status, superoxide dismutase and uric acid values in the CF group were higher by 15%, 35% and 31%, respectively, than in both control groups.
Cystic fibrosis patients demonstrated altered salivary profile, especially in antioxidant enzymatic and molecular activity, possibly resulting from the oral cavity's ongoing inflammatory and oxidative process. Free radical mechanisms may be involved in CF pathogenesis.
囊性纤维化（CF）的特征是外分泌改变；然而，尚未发表 CF 浆液和粘液唾液分泌物的综合成分谱。
我们分析了唾液流量和成分以及与氧化应激相关的参数，将 CF 患者与非 CF 支气管扩张症患者和健康对照组进行了比较。
CF 患者的唾液镁浓度和乳酸脱氢酶活性中位数明显低于健康对照组。CF 患者的唾液总蛋白浓度比非 CF 支气管扩张症患者高 45%。CF 患者的过氧化物酶水平比非 CF 支气管扩张症低 8%。CF 组的唾液总抗氧化状态、超氧化物歧化酶和尿酸值分别比两个对照组高 15%、35%和 31%。
CF 患者的唾液谱发生了改变，特别是在抗氧化酶和分子活性方面，这可能是口腔持续的炎症和氧化过程的结果。自由基机制可能参与 CF 的发病机制。
