San Francisco VA Medical Center, San Francisco, CA 94121, USA.
Am J Kidney Dis. 2013 Sep;62(3):595-603. doi: 10.1053/j.ajkd.2013.03.027. Epub 2013 May 20.
Kidney function monitoring using creatinine-based glomerular filtration rate estimation is a routine part of clinical practice. Emerging evidence has shown that cystatin C may improve classification of glomerular filtration rate for defining chronic kidney disease in certain clinical populations and assist in understanding the complications of chronic kidney disease. In this review and update, we summarize the overall literature on cystatin C, critically evaluate recent high-impact studies, highlight the role of cystatin C in recent kidney disease guidelines, and suggest a practical approach for clinicians to incorporate cystatin C into practice. We conclude by addressing frequently asked questions related to implementing cystatin C use in a clinical setting.
使用基于肌酐的肾小球滤过率估计进行肾功能监测是临床实践的常规部分。新出现的证据表明，胱抑素 C 可能会改善某些临床人群中肾小球滤过率的分类，以定义慢性肾脏病，并有助于了解慢性肾脏病的并发症。在本次综述和更新中，我们总结了胱抑素 C 的总体文献，批判性地评估了最近的高影响力研究，强调了胱抑素 C 在最近的肾脏病指南中的作用，并为临床医生提出了将胱抑素 C 纳入实践的实用方法。最后，我们回答了与在临床环境中实施胱抑素 C 使用相关的常见问题。
