Abidu-Figueiredo Marcelo, Costa Waldemar Silva, Chagas Maurício Alves, Sampaio Francisco José Barcellos, Cardoso Luiz Eduardo de Macedo
Urogenital Research Unit, State University of Riode Janeiro,RJ, Brazil.
Acta Cir Bras. 2013 May;28(5):378-84. doi: 10.1590/s0102-86502013000500010.
To investigate whether elastic fiber content in the corpus cavernosum (CC), corpus spongiosum (CS) and tunica albuginea (TA) of the rabbit penis undergoes modifications with age.
Rabbits were sacrificed, in groups of ten animals each, at 30, 120, 240, and 730 days of age. Histological sections were obtained from the penile middle shaft and were stained with Weigert's resorsin fuchsin. The content of elastic fibers was determined using stereological methods, and was expressed as volume fraction.
At 730 days of age, elastic fiber content was increased by 54% (p<0.004), 78% (p<0.004), and 87% (p<0.004) in the TA, CC, and CS, respectively, compared with animals aged 30 days. After 30 days of age, the concentration gradually and significantly increased until 240 days of age. In 730-day old animals, the concentration, compared with the previous age group, was unchanged in the CC and decreased by 20% (p<0.004) in the TA.
Elastic fiber contents in the rabbit penis correlate with properties of penile tissues. Although after one month of age there is a gradual increase in these concentrations, in two-year old animals this trend is interrupted, which suggests that this could be an early alteration due to senescence.
研究兔阴茎海绵体（CC）、尿道海绵体（CS）和白膜（TA）中的弹性纤维含量是否随年龄发生变化。
将兔子按每组10只进行处死，年龄分别为30天、120天、240天和730天。从阴茎中轴获取组织学切片，并用魏格特间苯二酚品红染色。使用体视学方法测定弹性纤维含量，并以体积分数表示。
与30日龄的动物相比，730日龄时，TA、CC和CS中的弹性纤维含量分别增加了54%（p<0.004）、78%（p<0.004）和87%（p<0.004）。30日龄后，浓度逐渐显著增加，直至240日龄。在730日龄的动物中，与前一年龄组相比，CC中的浓度未发生变化，TA中的浓度下降了20%（p<0.004）。
兔阴茎中的弹性纤维含量与阴茎组织的特性相关。虽然在1月龄后这些浓度逐渐增加，但在2岁的动物中这种趋势被打断，这表明这可能是衰老导致的早期改变。
