Australian Centre for Microscopy and Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia.
Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3530-6. doi: 10.1016/j.msec.2013.04.044. Epub 2013 Apr 29.
High strength, low Young's modulus and good biocompatibility are desirable but difficult to simultaneously achieve in metallic implant materials for load bearing applications, and these impose significant challenges in material design. Here we report that a nano-grained β-Ti alloy prepared by high-pressure torsion exhibits remarkable mechanical and biological properties. The hardness and modulus of the nano-grained Ti alloy were respectively 23% higher and 34% lower than those of its coarse-grained counterpart. Fibroblast cell attachment and proliferation were enhanced, demonstrating good in vitro biocompatibility of the nano-grained Ti alloy, consistent with demonstrated increased nano-roughness on the nano-grained Ti alloy. Results suggest that the nano-grained β-Ti alloy may have significant application as an implant material in dental and orthopedic applications.
高强度、低杨氏模量和良好的生物相容性是承重应用中金属植入材料所期望的特性，但很难同时实现，这给材料设计带来了重大挑战。在这里，我们报告了一种通过高压扭转制备的纳米晶β-Ti 合金，它具有显著的机械和生物学性能。纳米晶 Ti 合金的硬度和模量分别比其粗晶对应物高 23%和低 34%。成纤维细胞的黏附和增殖得到增强，表明纳米晶 Ti 合金具有良好的体外生物相容性，这与纳米晶 Ti 合金表面纳米粗糙度的增加相一致。研究结果表明，纳米晶β-Ti 合金可能作为一种植入材料在牙科和骨科应用中有重要的应用前景。
