Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
J Pediatr. 2013 Sep;163(3):666-71.e1. doi: 10.1016/j.jpeds.2013.04.001. Epub 2013 May 21.
To assess whether there was an adverse effect on brain growth after hydrocortisone (HC) treatment for bronchopulmonary dysplasia (BPD) in a large cohort of infants without dexamethasone exposure.
Infants who received HC for BPD between 2005 and 2011 and underwent magnetic resonance imaging at term-equivalent age were included. Control infants born in Geneva (2005-2006) and Utrecht (2007-2011) were matched to the infants treated with HC according to segmentation method, sex, and gestational age. Infants with overt parenchymal pathology were excluded. Multivariable analysis was used to determine if there was a difference in brain volumes between the 2 groups.
Seventy-three infants treated with HC and 73 matched controls were included. Mean gestational age was 26.7 weeks, and mean birth weight was 906 g. After correction for gestational age, postmenstrual age at time of scanning, the presence of intraventricular hemorrhage, and birth weight z-score, no differences were found between infants treated with HC and controls in total brain tissue or cerebellar volumes.
In the absence of associated parenchymal brain injury, no reduction in brain tissue or cerebellar volumes could be found at term-equivalent age between infants with or without treatment with HC for BPD.
在无地塞米松暴露的大样本婴儿队列中，评估接受氢化可的松（HC）治疗支气管肺发育不良（BPD）后对脑生长是否存在不良影响。
纳入了 2005 年至 2011 年期间因 BPD 接受 HC 治疗且在胎龄相当年龄行磁共振成像检查的婴儿。根据分段方法、性别和胎龄，将出生于日内瓦（2005-2006 年）和乌得勒支（2007-2011 年）的对照婴儿与接受 HC 治疗的婴儿相匹配。排除明显实质病变的婴儿。采用多变量分析来确定两组之间脑容量是否存在差异。
纳入了 73 名接受 HC 治疗的婴儿和 73 名匹配的对照婴儿。平均胎龄为 26.7 周，平均出生体重为 906 克。在校正胎龄、扫描时的校正胎龄、是否存在脑室周围出血以及出生体重 z 评分后，接受 HC 治疗的婴儿与对照组在总脑组织或小脑体积方面无差异。
在无相关实质脑损伤的情况下，在胎龄相当的年龄，BPD 接受或未接受 HC 治疗的婴儿之间，脑组织或小脑体积无减少。
