Kaga Makiko, Inagaki Masumi, Ohta Reiko
National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan.
National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan.
Brain Dev. 2014 Apr;36(4):284-6. doi: 10.1016/j.braindev.2013.04.012. Epub 2013 May 21.
We aimed to determine the incidence and prevalence of LKS in Japanese children.
A questionnaire was sent to all 3004 Japanese hospitals that have a department of pediatrics. The questionnaire asked for the number of first-visit LKS patients and LKS patients who were followed up at or visited their clinic during the past one year Vital statistics of the same year (2008) published by Ministry of Health, Labor and Welfare, Japan were referenced to calculate the estimated incidence and prevalence of LKS among Japanese children.
Chiefs of 1562 pediatric departments answered our inquiry (51.9% of returns). Six chiefs had one new LKS patient, aged 6-14 years. Thirty two patients with LKS were followed in the same period. The number of children with LKS less than 20 years of age who needed medical care was at least 23 and at most 31. Vital statistics of Japan 2009 revealed that the population of children aged 5-14 years was 11,861,464 and that aged 5-19 years was 18,007,968.
The number of the first-visit LKS patients was 6 in a year. We estimated the incidence of LKS in the 5- to 14-years-old Japanese population as about 1 in 978,000. The number of LKS patients aged 5-19 was estimated to range from 44.2 to 59.6 among a population of 18,007,968. This means the prevalence of LKS under medical care is roughly one in 302,147-407,420 children aged 5-19. This study is the first epidemiological estimation of the incidence and prevalence of children with LKS in Japan or, for that matter, in any other area.
(1) Incidence of children with LKS aged 5-14 years was about 1 in a million in Japan. (2) Prevalence of children with LKS aged 5-19 and under medical care was one in about 300,000-410,000 in Japan. (3) This study constitutes the first epidemiological estimation of LKS in Japan.
我们旨在确定日本儿童 Landau-Kleffner 综合征（LKS）的发病率和患病率。
向所有设有儿科的 3004 家日本医院发送了调查问卷。问卷询问了初诊 LKS 患者的数量以及过去一年在其诊所接受随访或就诊的 LKS 患者数量。参考日本厚生劳动省公布的同一年（2008 年）的人口动态统计数据，计算日本儿童中 LKS 的估计发病率和患病率。
1562 个儿科科室的主任回复了我们的询问（回复率为 51.9%）。6 位主任表示有 1 例新的 LKS 患者，年龄在 6 - 14 岁之间。同期有 32 例 LKS 患者接受随访。需要医疗护理的 20 岁以下 LKS 儿童数量至少为 23 例，最多为 31 例。2009 年日本的人口动态统计显示，5 - 14 岁儿童人口为 11,861,464 人，5 - 19 岁儿童人口为 18,007,968 人。
一年中初诊 LKS 患者有 6 例。我们估计 5 至 14 岁日本人群中 LKS 的发病率约为每 978,000 人中有 1 例。在 18,007,968 人的人群中，5 - 19 岁的 LKS 患者估计有 44.2 至 59.6 例。这意味着接受医疗护理的 5 - 19 岁儿童中 LKS 的患病率约为每 302,147 - 407,420 名儿童中有 1 例。本研究是对日本或其他任何地区 LKS 儿童发病率和患病率的首次流行病学估计。
（1）日本 5 - 14 岁 LKS 儿童的发病率约为百万分之一。（2）日本 5 - 19 岁且接受医疗护理的 LKS 儿童患病率约为每 300,000 - 410,000 人中有 1 例。（3）本研究是日本对 LKS 的首次流行病学估计。
