多能性的新平衡：谱系特化因子重编程。

New balance in pluripotency: reprogramming with lineage specifiers.

机构信息

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

出版信息

Cell. 2013 May 23;153(5):939-40. doi: 10.1016/j.cell.2013.04.051.

DOI:10.1016/j.cell.2013.04.051

PMID:23706730

Abstract

Induction of pluripotency in somatic cells has been achieved by myriad combinations of transcription factors that belong to the core pluripotency circuitry. In this issue, Shu et al. report reprogramming with lineage specifiers, lending support to the view of the pluripotent state as a fine balance between competing differentiation forces.

摘要

体细胞的多能性诱导已经通过属于核心多能性回路的转录因子的无数组合来实现。在本期杂志中，Shu 等人报告了使用谱系指定因子进行重编程，这为多能状态是分化力量竞争之间的微妙平衡的观点提供了支持。