The MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Genomics Proteomics Bioinformatics. 2013 Oct;11(5):259-63. doi: 10.1016/j.gpb.2013.09.005. Epub 2013 Oct 4.
Pluripotency-associated factors and their rivals, lineage specifiers, have long been considered the determining factors for the identity of pluripotent and differentiated cells, respectively. Therefore, factors that are employed for cellular reprogramming in order to induce pluripotency have been identified mainly from embryonic stem cell (ESC)-enriched and pluripotency-associated factors. Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. In this review, we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifiers. We highlight the value of the "seesaw" model in defining cellular identity, opening up a novel scenario to consider pluripotency and lineage specification.
多能性相关因子及其对手，谱系指定因子，长期以来一直被认为分别是多能性和分化细胞身份的决定因素。因此，为了诱导多能性而用于细胞重编程的因子主要来自胚胎干细胞（ESC）富集和多能性相关因子。最近，谱系指定因子被确定在协调恢复多能性的过程中发挥重要作用。在这篇综述中，我们总结了使用多能性相关因子和谱系指定因子进行细胞命运转换的最新发现。我们强调了“跷跷板”模型在定义细胞身份方面的价值，为考虑多能性和谱系指定开辟了一个新的场景。
