调控早期转录的转变。
Transitions for regulating early transcription.
机构信息
Gene Center Munich and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
出版信息
Cell. 2013 May 23;153(5):943-4. doi: 10.1016/j.cell.2013.04.050.
PMID:23706732
Abstract
Gene expression is largely regulated during the initiation of RNA polymerase II (PolII) transcription. In this issue, Kouzine et al. show that control of DNA melting is one of the critical rate-limiting steps for productive mRNA elongation. We discuss these findings in the context of other key energetic transitions.
摘要
基因表达在 RNA 聚合酶 II（PolII）转录起始过程中被广泛调控。在本期杂志中，Kouzine 等人表明 DNA 熔解的控制是促进 mRNA 延伸的关键限速步骤之一。我们将在其他关键能量转换的背景下讨论这些发现。
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