周末摇头丸的使用会破坏老鼠的记忆。
Weekend Ecstasy use disrupts memory in rats.
机构信息
The University of Texas at Austin, College of Pharmacy, Division of Pharmacology and Toxicology, 2409 University Avenue, Stop A1915, Austin, TX 78712, USA.
出版信息
Neurosci Lett. 2013 Aug 9;549:173-6. doi: 10.1016/j.neulet.2013.05.030. Epub 2013 May 22.
Abstract
3,4-methylenedioxymethamphetamine (MDMA, or "Ecstasy") is a popular recreational drug. However, its exposure is often limited to the weekends in a highly stimulating environment. The goal of this study was to investigate the behavioral domains of working and recognition memory within a model of "weekend" Ecstasy use. Rats self-administered MDMA during 2-h sessions on two consecutive days followed by five drug-free days. Coupling this intermittent dosing schedule with a novel object recognition task, we found non-spatial memory impaired after only two "weekends" of self-administered MDMA. Our findings suggest that MDMA at recreational use levels can disrupt memory processes.
摘要
3,4-亚甲二氧基甲基苯丙胺（MDMA，或“摇头丸”）是一种流行的娱乐性药物。然而，它的使用通常仅限于在高度刺激的环境中度过周末。本研究的目的是在“周末”使用摇头丸的模型中研究工作和识别记忆的行为领域。大鼠在连续两天的 2 小时疗程中自行给予 MDMA，然后是 5 天无药物期。将这种间歇性给药方案与新物体识别任务相结合，我们发现仅经过两个“周末”的自我给予 MDMA 后，非空间记忆受损。我们的研究结果表明，在娱乐性使用水平下，MDMA 可能会破坏记忆过程。
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