Khamzamulin R O, Chargynov K S, Koz'min M G, Davletova R A
Klin Med (Mosk). 1990 Apr;68(4):66-9.
The response of cardiovascular system to acetylcholine inhalation has been studied in 10 patients with bronchial asthma in remission. With the threshold dose of the drug, i.e. at less than or equal to 20% reduction of the forced expiration volume per 1 sec, there appeared increased cardiac beating and output, elevated pressure in the pulmonary artery, ECG sings of a sharp overload in the right atrium. The shifts in the cardiac function resulted from a fall in alveolar pO2 produced by acetylcholine-related bronchial obstruction and following hypoxic vasoconstriction of the lesser circulation. The findings emphasize the need in the cardiovascular system control when performing the acetylcholine test for bronchial reactivity.
对10例缓解期支气管哮喘患者吸入乙酰胆碱后心血管系统的反应进行了研究。使用该药物的阈剂量时，即一秒用力呼气量减少小于或等于20%时，出现心跳和心输出量增加、肺动脉压升高、右心房明显超负荷的心电图体征。心功能的改变是由乙酰胆碱相关支气管阻塞导致的肺泡pO2下降以及随后小循环的缺氧性血管收缩引起的。这些发现强调了在进行支气管反应性乙酰胆碱试验时对心血管系统进行监测的必要性。
