Walters E H
Thorax. 1983 Mar;38(3):195-9. doi: 10.1136/thx.38.3.195.
Two groups of normal subjects were immunised with live attenuated influenza virus given by the intranasal route. One group was then treated with placebo capsules for 48 hours. At the end of this time an increase in sensitivity to inhaled histamine was found but with a coincident decrease in reactivity. The other group was treated with indomethacin (50 mg four times daily). The increase in sensitivity associated with influenza vaccination was prevented but there was a significant increase in reactivity. It is proposed that prostaglandins released as part of the inflammatory response in the airways after viral infection may be concerned in induction of the changes in response to histamine observed under these conditions.
两组正常受试者通过鼻内途径接种减毒活流感病毒进行免疫。然后一组受试者服用安慰剂胶囊48小时。在此期间结束时，发现对吸入组胺的敏感性增加，但反应性同时降低。另一组受试者服用吲哚美辛（每日4次，每次50毫克）。与流感疫苗接种相关的敏感性增加得到了预防，但反应性显著增加。有人提出，病毒感染后气道炎症反应中释放的前列腺素可能与在这些条件下观察到的对组胺反应变化的诱导有关。
