用气相色谱法同时测定血浆中乙酰水杨酸、水杨酸和水杨酰胺的含量。
A simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in plasma by gas liquid chromatography.
作者信息
Rance M J, Jordan B J, Nichols J D
出版信息
J Pharm Pharmacol. 1975 Jun;27(6):425-9. doi: 10.1111/j.2042-7158.1975.tb09472.x.
A novel method for the simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in biological fluids by gas liquid chromatography is described. The assay has been used to determine the plasma concentration of salicylates in 10 volunteers after oral ingestion of three commercially available aspirin-containing formulations. No difficulty was encountered in determining low concentrations of acetylsalicylic acid in the presence of higher concentrations of salicylic acid. The in vivo plasma half life of acetylsalicylic acid in man was found to be 15.5 min.
本文描述了一种通过气液色谱法同时测定生物流体中乙酰水杨酸、水杨酸和水杨酰胺的新方法。该测定法已用于测定10名志愿者口服三种市售含阿司匹林制剂后血浆中水杨酸盐的浓度。在高浓度水杨酸存在的情况下，测定低浓度的乙酰水杨酸没有遇到困难。发现人体内乙酰水杨酸的血浆半衰期为15.5分钟。
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