阿司匹林用于术后牙痛的疗效及药代动力学
Efficacy and pharmacokinetics of aspirin in post-operative dental pain.
作者信息
Seymour R A, Rawlins M D
出版信息
Br J Clin Pharmacol. 1982 Jun;13(6):807-10. doi: 10.1111/j.1365-2125.1982.tb01870.x.
Abstract
1 Soluble aspirin, 600 mg and 1200 mg, and placebo were compared in a double-blind, cross-over study in 12 patients with post-operative pain following removal of impacted lower third molars. 2 Significant analgesia after 600 mg aspirin occurred only at 45 min after administration, whereas significant analgesia after 1200 mg aspirin occurred from 45 to 240 min. The 1200 mg dose produced greater analgesia than the 600 mg dose and is to be recommended in clinical practice. 3 Plasma concentrations of salicylate and acetylsalicylate were measured after both doses. A significant correlation (rs = 0.876, P less than 0.01) was observed between analgesia and plasma salicylate concentration after 1200 mg aspirin.
摘要
- 在一项双盲交叉研究中，对12例拔除下颌阻生第三磨牙后出现术后疼痛的患者，比较了600毫克和1200毫克的可溶性阿司匹林及安慰剂的效果。2. 600毫克阿司匹林给药后仅在45分钟时出现显著镇痛作用，而1200毫克阿司匹林给药后45至240分钟出现显著镇痛作用。1200毫克剂量产生的镇痛作用比600毫克剂量更强，在临床实践中推荐使用。3. 两种剂量给药后均测量了水杨酸盐和乙酰水杨酸盐的血浆浓度。服用1200毫克阿司匹林后，观察到镇痛作用与血浆水杨酸盐浓度之间存在显著相关性（rs = 0.876，P小于0.01）。
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