新型双组分 NsrRS 和 LcrRS 系统参与了不同的抗纽莫西林 A 和 nukacin ISK-1 抗性途径在变异链球菌中的作用。
Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.
机构信息
Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
出版信息
Appl Environ Microbiol. 2013 Aug;79(15):4751-5. doi: 10.1128/AEM.00780-13. Epub 2013 May 24.
Abstract
The novel two-component systems NsrRS and LcrRS are individually associated with resistance against the distinct lantibiotics nisin A and nukacin ISK-1 in Streptococcus mutans. NsrRS regulates the expression of NsrX, which is associated with nisin A binding, and LcrRS regulates the expression of the ABC transporter LctFEG.
摘要
新型双组份系统 NsrRS 和 LcrRS 分别与变链菌中不同的羊毛硫抗生素乳链菌肽 A 和 nukacin ISK-1 的抗性有关。NsrRS 调节与乳链菌肽 A 结合有关的 NsrX 的表达，而 LcrRS 调节 ABC 转运体 LctFEG 的表达。
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