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Monitoring of the multiple bacteriocin production by Enterococcus faecium NKR-5-3 through a developed liquid chromatography and mass spectrometry-based quantification system.通过开发的液相色谱和质谱定量系统监测粪肠球菌 NKR-5-3 多种细菌素的生产。
J Biosci Bioeng. 2012 Nov;114(5):490-6. doi: 10.1016/j.jbiosc.2012.06.003. Epub 2012 Jul 3.
2
A genome-wide study of two-component signal transduction systems in eight newly sequenced mutans streptococci strains.对 8 株新测序变形链球菌中双组分信号转导系统的全基因组研究。
BMC Genomics. 2012 Apr 4;13:128. doi: 10.1186/1471-2164-13-128.
3
Bacitracin and nisin resistance in Staphylococcus aureus: a novel pathway involving the BraS/BraR two-component system (SA2417/SA2418) and both the BraD/BraE and VraD/VraE ABC transporters.金黄色葡萄球菌中杆菌肽和乳链菌肽抗性：涉及 BraS/BraR 双组分系统（SA2417/SA2418）和 BraD/BraE 及 VraD/VraE ABC 转运体的新途径。
Mol Microbiol. 2011 Aug;81(3):602-22. doi: 10.1111/j.1365-2958.2011.07735.x. Epub 2011 Jul 4.
4
The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans.BceABRS 四元系统调控变链菌中棒曲霉素诱导的细胞包膜应激反应。
Antimicrob Agents Chemother. 2010 Sep;54(9):3895-906. doi: 10.1128/AAC.01802-09. Epub 2010 Jul 6.
5
Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin.肺炎链球菌对三种不同抗菌肽（杆菌肽、LL-37 和乳链菌肽）挑战的一般和特定适应性反应。
Antimicrob Agents Chemother. 2010 Jan;54(1):440-51. doi: 10.1128/AAC.00769-09. Epub 2009 Nov 16.
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Lantibiotics: mode of action, biosynthesis and bioengineering.羊毛硫抗生素：作用模式、生物合成与生物工程
Curr Pharm Biotechnol. 2009 Jan;10(1):2-18. doi: 10.2174/138920109787048616.
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Isolation and partial characterization of the Streptococcus mutans type AII lantibiotic mutacin K8.变形链球菌AII型羊毛硫抗生素变链菌素K8的分离及部分特性分析
Microbiology (Reading). 2007 May;153(Pt 5):1631-1641. doi: 10.1099/mic.0.2006/003756-0.
8
Lantibiotics: insight and foresight for new paradigm.羊毛硫抗生素：新范式的洞察与展望
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Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system.枯草芽孢杆菌中LiaRS依赖性基因表达的调控：保守的细胞膜应激感应双组分系统的抑制蛋白、调节因子结合位点及靶基因的鉴定
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Bacteriocins: developing innate immunity for food.细菌素：为食品开发天然免疫
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新型双组分 NsrRS 和 LcrRS 系统参与了不同的抗纽莫西林 A 和 nukacin ISK-1 抗性途径在变异链球菌中的作用。

Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.

机构信息

Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

出版信息

Appl Environ Microbiol. 2013 Aug;79(15):4751-5. doi: 10.1128/AEM.00780-13. Epub 2013 May 24.

DOI:10.1128/AEM.00780-13
PMID:23709506
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3719517/
Abstract

The novel two-component systems NsrRS and LcrRS are individually associated with resistance against the distinct lantibiotics nisin A and nukacin ISK-1 in Streptococcus mutans. NsrRS regulates the expression of NsrX, which is associated with nisin A binding, and LcrRS regulates the expression of the ABC transporter LctFEG.

摘要

新型双组份系统 NsrRS 和 LcrRS 分别与变链菌中不同的羊毛硫抗生素乳链菌肽 A 和 nukacin ISK-1 的抗性有关。NsrRS 调节与乳链菌肽 A 结合有关的 NsrX 的表达，而 LcrRS 调节 ABC 转运体 LctFEG 的表达。