Liaskos Christos, Rigopoulou Eirini I, Orfanidou Timoklia, Bogdanos Dimitrios P, Papandreou Christos N
Cellular Immunotherapy and Molecular Immunodiagnostics, Institute of Research and Technology Thessaly, 41222 Larissa, Greece.
Clin Dev Immunol. 2013;2013:968041. doi: 10.1155/2013/968041. Epub 2013 Apr 22.
CUZD1, the CUB, and zona pellucida-like domains-containing protein 1, is a newly identified antigen of pancreatic autoantibodies (PAB) giving a reticulogranular pattern in patients with inflammatory bowel diseases, and in particular Crohn's disease. The exact mechanisms by which this pancreatic antigen becomes the target of IBD-specific pancreatic autoantibodies are unclear. At the same time, evolving data strongly support a role for CUZD1 in carcinogenesis. Human CUZD1 is mapped at chromosome 10q26.13 and the loss of this region is a frequent event in various malignant tumours. mRNA overexpression of CUZD1 has been noted in ovarian cancer and serum levels of CUZD1 are elevated in women with ovarian cancer and patients suffering from pancreatic cancer. CUZD1 appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs. This review discusses the role of CUZD1 in cancer and autoimmunity. We anticipate that a better understanding of the function of CUZD1 will help us to understand how it becomes the focus of an autoimmune attack specifically targeting the intestine and its enigmatic role in carcinogenesis.
CUZD1，即含CUB和透明带样结构域蛋白1，是一种新发现的胰腺自身抗体（PAB）抗原，在炎症性肠病患者，尤其是克罗恩病患者中呈现网状颗粒样模式。这种胰腺抗原成为IBD特异性胰腺自身抗体靶点的确切机制尚不清楚。与此同时，不断发展的数据有力地支持了CUZD1在致癌过程中的作用。人类CUZD1定位于染色体10q26.13，该区域的缺失在各种恶性肿瘤中是常见事件。在卵巢癌中已发现CUZD1的mRNA过表达，卵巢癌女性患者和胰腺癌患者的血清CUZD1水平升高。CUZD1似乎是相对较少的生物标志物之一，在与癌性器官无关的自身免疫性疾病中既作为癌症生物标志物又作为自身抗体的自身抗原。本文综述了CUZD1在癌症和自身免疫中的作用。我们预计，更好地了解CUZD1的功能将有助于我们理解它如何成为特异性靶向肠道的自身免疫攻击的焦点以及它在致癌过程中的神秘作用。
