N-乙酰半胱氨酸可改善胰腺微循环，减轻急性坏死性胰腺炎的严重程度。
N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis.
机构信息
Department of Hepatobiliopancreatic Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China. ; Department of Gastroenterology Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
出版信息
Gut Liver. 2013 May;7(3):357-62. doi: 10.5009/gnl.2013.7.3.357. Epub 2013 Apr 25.
BACKGROUND/AIMS: To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP).
METHODS
Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination.
RESULTS
The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced.
CONCLUSIONS
NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.
背景/目的：研究 N-乙酰半胱氨酸（NAC）对急性坏死性胰腺炎（ANP）胰腺微血管灌注的有益作用。
方法
54 只大鼠分为对照组、ANP 组和 NAC 治疗组。通过逆行胰管内注射 3%牛磺胆酸钠建立 ANP 模型。NAC 治疗组在诱导 ANP 前 2 小时和后 30 分钟静脉输注 NAC。使用激光多普勒血流仪测量胰腺微血管灌注，并收集胰腺样本进行组织学检查。
结果
NAC 治疗组的微血管灌注略有下降，与 ANP 组相比，显著增加（p<0.01）。组织病理学检查显示，水肿和炎症浸润减轻，胰腺出血和坏死明显减少。
结论
NAC 可改善胰腺微血管灌注，减轻牛磺胆酸钠诱导的 ANP 的严重程度，可能为预防 ANP 进展提供一种新的治疗方法。
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