Department of General Surgery, Hangzhou First People's Hospital, Hangzhou, 310006, Zhejiang Province, China.
Inflammation. 2010 Aug;33(4):259-66. doi: 10.1007/s10753-010-9180-9.
To observe the protecting effects and mechanisms of Dexamethasone and Salviae miltiorrhizae on intestinal mucosa and immune organs (spleen, thymus and lymph node) in rats with severe acute pancreatitis (SAP). The rats were randomly divided into sham-operated, model control, Dexamethasone treated group and Salviae miltiorrhizae treated group. At 3, 6 and 12 h after operation, the mortality rate, pathological changes of intestinal mucosa and immune organs as well as the contents of serum PAF, IL-1 beta and sIL-2R were observed, respectively. The mortality rate and the contents of PAF (at 3 and 6 h), IL-1 beta (at all time points) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 h) in Dexamethasone treated group were significantly lower than those in model control groups (P < 0.05). The contents of PAF (at 3 and 12 h), IL-1 beta (at 6 and 12 h) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 and 12 h) in Salviae miltiorrhizae treated group were markedly lower than those in model control groups (P < 0.05). Since both Dexamethasone and Salvia miltiorrhizae can reduce the contents of serum PAF, sIL-2R and IL-1 beta, mitigate the pathological changes in the small intestine, spleen and thymus and reduce the mortality rate of SAP rats, they show good therapeutic effects on SAP rats.
观察地塞米松和丹参对重症急性胰腺炎（SAP）大鼠肠黏膜及免疫器官（脾、胸腺、淋巴结）的保护作用及其机制。将大鼠随机分为假手术组、模型对照组、地塞米松组和丹参组。术后 3、6、12 h 观察各组大鼠死亡率、肠黏膜及免疫器官病理变化和血清 PAF、IL-1β、sIL-2R 含量。地塞米松组大鼠死亡率和血清 PAF 含量（3、6 h）、IL-1β含量（各时间点）、sIL-2R 含量（3、6 h）以及胸腺病理评分（各时间点）、脾病理评分（3 h）均显著低于模型对照组（P＜0.05）。丹参组大鼠血清 PAF 含量（3、12 h）、IL-1β含量（6、12 h）、sIL-2R 含量（3、6 h）以及胸腺病理评分（各时间点）、脾病理评分（3、12 h）均显著低于模型对照组（P＜0.05）。地塞米松和丹参均可降低 SAP 大鼠血清 PAF、sIL-2R、IL-1β含量，减轻小肠、脾脏、胸腺病理变化，降低 SAP 大鼠死亡率，对 SAP 大鼠有较好的治疗作用。
