Vucovich Megan, Ehinger Noah, Poole Stanley D, Lamb Fred S, Reese Jeff
Vanderbilt University School of Medicine, Nashville, TN.
EJ Neonatol Res. 2012 Jan;2(1):13-24.
The mechanisms that regulate relaxation of the fetal ductus arteriosus (DA) and its postnatal constriction are the subject of ongoing studies. Using pressure myography, a pattern of rhythmic oscillatory contractions termed vasomotion was observed in the isolated DA of preterm (day 15) fetal mice. Vasomotion was enhanced by oxygen-induced DA constriction and other contractile agents, and diminished by vasodilatory stimuli or inhibition of chloride channels. The DA of late preterm (day 17) or term (day 19) gestation fetal mice did not exhibit vasomotion. These studies establish the stage-specific presence of vasomotion in the DA of fetal mice and suggest that complex events contribute to intrinsic mechanisms for control of fetal DA tone.
调节胎儿动脉导管（DA）舒张及其出生后收缩的机制是目前研究的主题。使用压力肌动描记法，在早产（第15天）胎儿小鼠的离体DA中观察到一种称为血管运动的节律性振荡收缩模式。血管运动因氧诱导的DA收缩和其他收缩剂而增强，并因血管舒张刺激或氯通道抑制而减弱。妊娠晚期早产（第17天）或足月（第19天）胎儿小鼠的DA未表现出血管运动。这些研究确定了胎儿小鼠DA中血管运动的阶段特异性存在，并表明复杂事件有助于控制胎儿DA张力的内在机制。
