Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA.
Am J Gastroenterol. 2013 Oct;108(10):1558-63; quiz 1564. doi: 10.1038/ajg.2013.147. Epub 2013 May 28.
The objective of this systematic review and meta-analysis was to estimate the risk of developing functional dyspepsia (FD) following acute infectious gastroenteritis (IGE).
Eligible studies were identified through PubMed and EMBASE searches. Data and quality indicators were extracted by two authors from nine studies examining the risk of FD following IGE in 5,755 exposed individuals.
Estimates of FD risk following IGE based on a random effects model yielded a pooled odds ratio (OR) of 2.18 (95% confidence interval (CI): 1.70-2.81). Subanalyses revealed differences in the odds of FD following self-reported IGE (OR: 2.83, 95% CI: 2.10-3.81) compared with documented IGE medical encounters (OR: 1.81, 95% CI: 1.26-2.58), and a decreasing FD risk with time from IGE (≤12 months: OR: 4.76, 95% CI: 2.47-9.20 and >12 months: OR: 1.97, 95% CI: 1.51-2.56).
Taken together, these data suggest that the risk of developing FD is significantly increased following IGE.
本系统评价和荟萃分析的目的是评估急性感染性胃肠炎（IGE）后功能性消化不良（FD）的发病风险。
通过 PubMed 和 EMBASE 检索确定符合条件的研究。两位作者从 9 项研究中提取了 5755 名暴露个体中 IGE 后 FD 风险的数据和质量指标。
基于随机效应模型的 IGE 后 FD 风险估计得出的合并优势比（OR）为 2.18（95%置信区间（CI）：1.70-2.81）。亚分析显示，自我报告的 IGE 后 FD 的可能性（OR：2.83，95%CI：2.10-3.81）与有记录的 IGE 医疗就诊（OR：1.81，95%CI：1.26-2.58）存在差异，并且随着 IGE 时间的推移，FD 的风险呈下降趋势（≤12 个月：OR：4.76，95%CI：2.47-9.20 和>12 个月：OR：1.97，95%CI：1.51-2.56）。
综上所述，这些数据表明，IGE 后发生 FD 的风险显著增加。
