Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital Affiliated Shanghai University of Traditional Chinese Medicine, Shanghai 200031, PR China.
Asian Pac J Trop Med. 2013 Jun;6(6):493-6. doi: 10.1016/S1995-7645(13)60081-4.
To study the effect of atorvastatin on atherosclerotic rabbits.
A total of 60 New Zealand male rabbits were randomly divided into the normal group, model group and atorvastatin group. The replication rabbit atherosclerotic model with immune injury combined with a high fat diet feeding was used. All rabbits were sacrificed after 3 months. TLR4 and NF-κB p65 were observed by HE staining, immunohistochemistry and western blotting.
The expression of TLR4, NF-κB p65 were significantly increased in the model group compared with the normal group. The expression of TLR4 and NF-κB p65 decreased significantly in the atorvastatin group, and there was no difference compared with the normal group.
The effect of atorvastatin on atherosclerosis may be achieved by the inhibition of the expression of TLR4 and NF-κB p65.
研究阿托伐他汀对动脉粥样硬化兔的作用。
将 60 只新西兰雄性兔随机分为正常组、模型组和阿托伐他汀组。采用免疫损伤联合高脂饮食喂养复制兔动脉粥样硬化模型，所有兔于 3 个月后处死。通过 HE 染色、免疫组化和 Western blot 观察 TLR4 和 NF-κB p65。
与正常组相比，模型组 TLR4、NF-κB p65 表达明显增加。阿托伐他汀组 TLR4 和 NF-κB p65 的表达明显下降，与正常组相比差异无统计学意义。
阿托伐他汀对动脉粥样硬化的作用可能是通过抑制 TLR4 和 NF-κB p65 的表达来实现的。
