Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan.
Fetal Diagn Ther. 2013;34(3):176-9. doi: 10.1159/000348778. Epub 2013 May 24.
We report a case of mirror syndrome caused by parvovirus B19, which resolved after intra-uterine transfusion. Mirror syndrome is a rare condition characterised by a triad of foetal hydrops, generalized maternal oedema and placentomegaly. Although the mechanism underlying the onset of this syndrome is unknown, it probably shares a common pathophysiologic origin with pre-eclampsia. Our patient showed increased circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and decreased levels of placental growth factor (PlGF), which have also been reported in pre-eclampsia. The sFlt-1/PlGF ratio decreased immediately after intra-uterine transfusion, followed by resolution of both maternal and foetal symptoms. This suggests that the sFlt-1/PlGF ratio may help to predict the post-treatment course of mirror syndrome.
我们报告了一例由细小病毒 B19 引起的镜像综合征病例，该病例在宫内输血后得到缓解。镜像综合征是一种罕见的疾病，其特征为胎儿水肿、全身母体水肿和胎盘肿大三联征。尽管该综合征发病机制尚不清楚，但它可能与子痫前期具有共同的病理生理起源。我们的患者表现出循环中可溶性 fms 样酪氨酸激酶 1（sFlt-1）水平升高和胎盘生长因子（PlGF）水平降低，这些也在子痫前期中有所报道。宫内输血后，sFlt-1/PlGF 比值立即下降，随后母体和胎儿症状均得到缓解。这表明 sFlt-1/PlGF 比值可能有助于预测镜像综合征的治疗后病程。
