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妊娠期间的细小病毒B19感染——疾病进程、胎儿并发症及管理工具:病例系列与文献综述

Parvovirus B19 Infection in Pregnancy-Course of the Disease, Fetal Complications and Management Tools: A Case Series and Literature Review.

作者信息

Olejniczak Olga, Kornacki Jakub, Boroń Daniel, Gutaj Paweł, Iciek Rafał, Wender-Ożegowska Ewa

机构信息

Department of Reproduction, Chair of Reproduction and Perinatal Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Doctoral School, Poznan University of Medical Sciences, 60-701 Poznan, Poland.

出版信息

Children (Basel). 2024 Aug 24;11(9):1037. doi: 10.3390/children11091037.

DOI:10.3390/children11091037
PMID:39334570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11430279/
Abstract

Parvovirus B19 is a virus that causes a common and usually harmless infection in both children and adults. If the virus is transmitted transplacentally during pregnancy, it can have serious consequences for both the pregnant woman and the fetus. Potential complications include severe fetal anemia, which can lead to intrauterine fetal death. A common ultrasound finding in fetuses affected by parvovirus B19 is fetal edema, which is associated with a poor prognosis. Additionally, a rare but serious complication in pregnant women with parvovirus B19 infection is mirror syndrome. The diagnosis of parvovirus B19 infection during pregnancy necessitates close monitoring of the fetal condition. If fetal anemia is suspected, intrauterine transfusion is indicated to increase fetal survival. This study presents eight cases of parvovirus B19 infection in pregnant women, highlighting the various maternal-fetal complications encountered, along with diagnostic and treatment strategies.

摘要

细小病毒B19是一种在儿童和成人中引起常见且通常无害感染的病毒。如果该病毒在孕期经胎盘传播,可能会对孕妇和胎儿都造成严重后果。潜在并发症包括严重的胎儿贫血,这可能导致胎儿宫内死亡。感染细小病毒B19的胎儿常见的超声检查结果是胎儿水肿,这与预后不良有关。此外,感染细小病毒B19的孕妇中一种罕见但严重的并发症是镜像综合征。孕期细小病毒B19感染的诊断需要密切监测胎儿状况。如果怀疑胎儿贫血,应进行宫内输血以提高胎儿存活率。本研究呈现了8例孕妇感染细小病毒B19的病例,突出了所遇到的各种母胎并发症以及诊断和治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/52eb9a3446bb/children-11-01037-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/1b572365818e/children-11-01037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/c1af4c9b5dfe/children-11-01037-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/734a6c09893d/children-11-01037-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/d86428894849/children-11-01037-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/261d8ec62509/children-11-01037-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/cf2b876bb472/children-11-01037-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/850d15adeb11/children-11-01037-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/52eb9a3446bb/children-11-01037-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/1b572365818e/children-11-01037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/c1af4c9b5dfe/children-11-01037-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/734a6c09893d/children-11-01037-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/d86428894849/children-11-01037-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/261d8ec62509/children-11-01037-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/cf2b876bb472/children-11-01037-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/850d15adeb11/children-11-01037-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f30/11430279/52eb9a3446bb/children-11-01037-g008.jpg

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本文引用的文献

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Changing epidemiology of parvovirus B19 in the Netherlands since 1990, including its re-emergence after the COVID-19 pandemic.自 1990 年以来,荷兰的细小病毒 B19 流行病学发生变化,包括在 COVID-19 大流行后再次出现。
Sci Rep. 2024 Apr 26;14(1):9630. doi: 10.1038/s41598-024-59582-7.
2
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J Pers Med. 2024 Jan 26;14(2):139. doi: 10.3390/jpm14020139.
3
Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study.
103 例因微小病毒感染导致严重贫血的胎儿的宫内输血。一项多中心回顾性研究。
Arch Gynecol Obstet. 2023 Jul;308(1):117-125. doi: 10.1007/s00404-022-06712-z. Epub 2022 Aug 2.
4
Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays.在弓形体、细小病毒 B19、风疹病毒和巨细胞病毒(TORCH)诊断检测中,寨卡病毒检测的性能。
Clin Microbiol Rev. 2019 Dec 11;33(1). doi: 10.1128/CMR.00130-18. Print 2019 Dec 18.
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Performance of fetal middle cerebral artery peak systolic velocity for prediction of anemia in untransfused and transfused fetuses: systematic review and meta-analysis.胎儿大脑中动脉收缩期峰值速度预测未输血和输血胎儿贫血的效能:系统评价和荟萃分析。
Ultrasound Obstet Gynecol. 2019 Dec;54(6):722-731. doi: 10.1002/uog.20273.
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