Department of Oral Pathology & Microbiology, Gitam Dental College & Hospital, Gandhinagar Campus, Rushikonda, Vishakapatanam 530045, India.
Ann Diagn Pathol. 2013 Oct;17(5):421-4. doi: 10.1016/j.anndiagpath.2013.03.005. Epub 2013 May 24.
This study aimed to evaluate and correlate osteopontin (OPN) expression in oral squamous cell carcinoma (OSCC) and potentially malignant disorders including oral leukoplakia and oral submucous fibrosis (OSMF). Expression of OPN was investigated in 140 samples including OSCC, oral leukoplakia, and OSMF with or without dysplasia and normal oral mucosa. By using immunohistochemistry. Both intercellular and intracellular staining of the keratinocytes was considered to be positive, and intensity grading was assessed. Statistical analysis was done using analysis of variance. OPN positivity was detected in 85% cases of OSCC, 55% cases of oral leukoplakia, 35% cases of OSMF, and 60% cases of normal mucosa. These study highlights OPN as a biomarker for malignancy in the form of invasion but not to study progression from dysplasia to malignant transformation.
本研究旨在评估和关联骨桥蛋白（OPN）在口腔鳞状细胞癌（OSCC）和潜在的恶性疾病中的表达，包括口腔白斑病和口腔黏膜下纤维化（OSMF）。通过免疫组织化学，研究了 140 个样本中 OPN 的表达，包括有或无异型增生的 OSCC、口腔白斑病和口腔黏膜下纤维化以及正常口腔黏膜。角化细胞的细胞内和细胞间染色均被认为是阳性的，并进行了强度分级评估。采用方差分析进行统计分析。在 85%的 OSCC 病例、55%的口腔白斑病病例、35%的口腔黏膜下纤维化病例和 60%的正常黏膜病例中检测到 OPN 阳性。这些研究强调了 OPN 作为侵袭性恶性肿瘤的生物标志物，但不能研究从异型增生到恶性转化的进展。
