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A genetic deletion of the serotonin transporter greatly enhances the reinforcing properties of MDMA in rats.

作者信息

Oakly A C, Brox B W, Schenk S, Ellenbroek B A

机构信息

School of Psychology, Victoria University of Wellington, Wellington, New Zealand.

出版信息

Mol Psychiatry. 2014 May;19(5):534-5. doi: 10.1038/mp.2013.75. Epub 2013 May 28.

DOI:10.1038/mp.2013.75
PMID:23711978
Abstract
摘要

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In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat.安非他命类似物的体内效应揭示了 5-羟色胺能抑制大鼠中脑边缘多巴胺传递的证据。
J Pharmacol Exp Ther. 2011 Apr;337(1):218-25. doi: 10.1124/jpet.110.176271. Epub 2011 Jan 12.
3
MDMA ("ecstasy") abuse as an example of dopamine neuroplasticity.
遗传学与表观遗传学：敲除 5-羟色胺转运体的雄性青春期乙醇摄入与后代对乙醇的敏感性。
Psychopharmacology (Berl). 2022 Oct;239(10):3145-3159. doi: 10.1007/s00213-022-06195-5. Epub 2022 Aug 8.
4
Friend of the Devil: Negative Social Influences Driving Substance Use Disorders.《魔鬼的朋友：驱动物质使用障碍的负面社会影响》
Front Behav Neurosci. 2022 Feb 10;16:836996. doi: 10.3389/fnbeh.2022.836996. eCollection 2022.
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Lack of evidence for positive reinforcing and prosocial effects of MDMA in pair-housed male and female rats.缺乏 MDMA 对雄性和雌性群居大鼠具有正强化和亲社会作用的证据。
Eur J Pharmacol. 2021 Dec 15;913:174646. doi: 10.1016/j.ejphar.2021.174646. Epub 2021 Nov 17.
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Physiol Behav. 2019 Feb 1;199:343-350. doi: 10.1016/j.physbeh.2018.12.007. Epub 2018 Dec 4.
以 MDMA（“摇头丸”）滥用为例探讨多巴胺神经可塑性。
Neurosci Biobehav Rev. 2011 Apr;35(5):1203-18. doi: 10.1016/j.neubiorev.2010.12.010. Epub 2010 Dec 22.
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Effect of D1-like and D2-like receptor antagonists on methamphetamine and 3,4-methylenedioxymethamphetamine self-administration in rats.D1样和D2样受体拮抗剂对大鼠甲基苯丙胺和3,4-亚甲基二氧甲基苯丙胺自我给药的影响。
Behav Pharmacol. 2009 Dec;20(8):688-94. doi: 10.1097/FBP.0b013e328333a28d.
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5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study.5-HTTLPR 多态性、心境障碍与 3 年随访研究中的 MDMA 使用情况。
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Neuroscience. 2007 Jun 8;146(4):1662-76. doi: 10.1016/j.neuroscience.2007.03.030. Epub 2007 Apr 30.
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3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice.在血清素转运体基因敲除小鼠中，3,4-亚甲基二氧甲基苯丙胺的自我给药行为被消除。
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