C.J. Gorter Center for High-Field MRI, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
C.J. Gorter Center for High-Field MRI, Leiden University Medical Center, Leiden, The Netherlands.
Alzheimers Dement. 2014 Jan;10(1):e19-26. doi: 10.1016/j.jalz.2013.02.002. Epub 2013 May 25.
Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).
T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.
Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).
Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.
尸检研究表明，高磁场磁共振成像（MRI）有可能在大脑皮层中可视化淀粉样蛋白沉积。本研究旨在测试这一假设在阿尔茨海默病（AD）患者。
对 16 例 AD 患者和 15 例对照进行 T2*-加权 MRI 检查。所有磁共振图像均通过视觉评估进行定性评分，并通过测量皮质灰质和海马的相移进行定量评分。进行统计分析以评估组间差异。
AD 患者在颞顶叶、额叶和顶叶区域的皮层相移增加（P<0.005），这与个体的简易精神状态检查评分呈负相关（r=-0.54，P<0.05）。
在 7 特斯拉 T2*-加权 MRI 上显示的 AD 患者皮质相移增加是 AD 的一种潜在的新生物标志物，可能反映了早期的淀粉样蛋白病理。
