Zhu Li, Wang Xin-yue, Yang Xue, Jing Shan, Zhou Bo, Huang Xiu-xia, Jia Xu
Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medcine, Beijing 100700, China.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Mar;33(3):346-50.
To observe the features of bronchopulmonary lesions in ulcerative colitis (UC) rats and the specificity with Fei and Dachang, thus providing reliance for the theory of "intestinal diseases involved Fei".
The UC rat model was duplicated by using rabbit intestine mucosa tissue allergenic model and TNBS-ethanol model. A normal rat group was set up as the control. The pulmonary functions [including inspiratory resistance (Ri), expiratory resistance (Re), forced vital capacity (FVC); FEV. 2/FVC, maximal voluntary ventilation (MVV), forced expiratory flow rate (FEF25% - 75%)], and indicators of liver and kidney functions [serum alanine aminotransferase (ALT), aspartate amino transferase (AST), blood urea nitrogen (BUN), and creatinine (Cr)] were detected in the two groups. The pathological changes of colon, lung, liver, and kidney were observed in the two groups.
Rats in the model group in both acute and chronic stages had weight loss, mucus and loose stool. Partial rats had such symptoms as dyspnea, shortness of breath, and wheezing. Compared with the normal group, the MW, FVC, FEV0.2 and FEF25% -75% in the acute stage; Ri, Re, MVV, FVC, and FEF25% - 75% in the chronic stage all significantly decreased (P <0.05, P <0.01), and FEV0.2/FVC significantly increased in the model group (P <0.05). The pathological results showed interstitial pneumonia and pulmonary interstitial fibrosis in the model group. But the indicators of liver and kidney functions were all in the normal range. No obvious pathological change was seen in the renal and liver tissues in the two groups.
UC could specifically induce bronchopulmonary lesions. Lung injury was one of UC's intestinal manifestations. The theory of "Fei and Dachang being interior-exteriorly correlated" was demonstrated from the theory of "intestinal diseases involved Fei".
观察溃疡性结肠炎（UC）大鼠支气管肺脏病变特点及与肺、大肠的特异性关系，为“肠病及肺”理论提供依据。
采用兔肠黏膜组织致敏法及TNBS -乙醇法复制UC大鼠模型，设正常大鼠组作为对照。检测两组大鼠肺功能[包括吸气阻力（Ri）、呼气阻力（Re）、用力肺活量（FVC）、第0.2秒用力呼气容积（FEV0.2）/FVC、最大自主通气量（MVV）、呼气流量峰值（FEF25% - 75%）]及肝肾功能指标[血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、血尿素氮（BUN）、肌酐（Cr）]，观察两组大鼠结肠、肺、肝、肾组织的病理变化。
模型组大鼠急、慢性期均出现体重减轻、黏液便及稀便，部分大鼠出现呼吸困难、气短、喘息等症状。与正常组比较，急性期模型组MW、FVC、FEV0.2及FEF25% - 75%；慢性期Ri、Re、MVV、FVC及FEF25% - 75%均显著降低（P <0.05，P <0.01），模型组FEV0.2/FVC显著升高（P <0.05）。病理结果显示模型组出现间质性肺炎及肺间质纤维化，但肝肾功能指标均在正常范围内，两组大鼠肾、肝组织未见明显病理改变。
UC可特异性诱导支气管肺脏病变，肺损伤是UC肠外表现之一，从“肠病及肺”理论论证了“肺与大肠相表里”理论。
