Wang Jian-Yun, Wang Xin-Yue, Wu Hua-Yang, Sun Hui-Yi, Liu Da-Ming, Zhang Wen, Jin Chen-Xi, Wang Shuo-Ren
Department of Gastroenterology, the Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100029, China.
Department of Gastroenterology, Dongzhimen Hospital, Beijing, 100700, China.
Chin J Integr Med. 2016 Dec;22(12):894-901. doi: 10.1007/s11655-014-1842-2. Epub 2014 Jun 18.
To investigated the involvement of pulmonary function impairment in ulcerative colitis (UC), to explore a scientific basis for the Chinese medicine (CM) theory of exterior-interior correlation between Lung (Fei) and Large intestine (Dachang).
Totally 120 patients with a diagnosis of UC were recruited and the demographics, clinical data, and blood samples were collected. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) concentrations were measured. Every patient accepted pulmonary function test and took chest radiograph (CXR).> RESULTS: Pulmonary function abnormalities were present in 72 of 120 patients. The median (interquartile range) vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), carbon monoxide diffusion capacity (DL) of lung, total lung capacity (TLC) and functional residual volume (FRV) were decreased in distal UC and pancolitis compared with ulcerative prochitis (P <0.0005). Male patients had increased VC, FEV/FVC, and residual volume (RV)/TLC compared with female (P <0.0005), but decreased DL and carbon monoxide iffusion capacity (K) of lung/alveolar ventilation (P <0.0005). Age was strongly correlated with RV (Spearman rank correlation coefficient (rs)=-0.57,P <0.0001), and RV/TLC (rs=0.48,P<0.0001). Age was also correlated with FEV/FVC (rs=-0.29, P=0.001), forced expiratory flow in 75% vital capacity (FEF75%, rs=-0.20, P=0.03), DL (rs=-0.21, P=0.02), TLC (rs=-0.25, P=0.006), and FRV (rs=-0.28, P=0.002). The course of disease was correlated with FEF75% (rs=-0.18, P=0.049) and K (rs=-0.19, P=0.036). Chest radiograph abnormalities were presented in 38 of 120. Pulmonary symptoms were presented in 10 of 120. Other extraintestinal complications were presented in 21 of 120.
Pulmonary function impairment was more frequently than other extraintestinal complications in UC patients, which may be affected by sex, age, extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine.
探讨溃疡性结肠炎（UC）患者肺功能损害情况，为中医肺与大肠表里相关理论提供科学依据。
选取120例UC患者，收集其人口统计学资料、临床数据及血样，检测C反应蛋白（CRP）和红细胞沉降率（ESR）浓度。所有患者均接受肺功能检查并拍摄胸部X线片（CXR）。
120例患者中72例存在肺功能异常。与溃疡性直肠炎相比，远端UC和全结肠炎患者的肺活量（VC）、用力肺活量（FVC）、第1秒用力呼气容积（FEV）、肺一氧化碳弥散量（DL）、肺总量（TLC）和功能残气量（FRV）的中位数（四分位数间距）降低（P<0.0005）。男性患者的VC、FEV/FVC和残气量（RV）/TLC高于女性（P<0.0005），但肺DL和一氧化碳弥散能力（K）/肺泡通气低于女性（P<0.0005）。年龄与RV（Spearman等级相关系数（rs）=-0.57，P<0.0001）及RV/TLC（rs=0.48，P<0.0001）密切相关。年龄还与FEV/FVC（rs=-0.29，P=0.001）、75%肺活量时的用力呼气流量（FEF75%，rs=-0.20，P=0.03）、DL（rs=-0.21，P=0.02）、TLC（rs=-0.25，P=0.006）及FRV（rs=-0.28，P=0.002）相关。病程与FEF75%（rs=-0.18，P=0.049）及K（rs=-0.19，P=0.036）相关。120例中有38例胸部X线片异常，120例中有10例有肺部症状，120例中有21例有其他肠外并发症。
UC患者肺功能损害较其他肠外并发症更为常见，可能受性别、年龄、病变范围及病程影响。这些结果可为肺与大肠表里相关理论提供科学依据。
