泛素蛋白酶体在肺生物学和疾病中的新兴作用。
The emerging role of the ubiquitin proteasome in pulmonary biology and disease.
机构信息
Acute Lung Injury Center of Excellence, Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, USA.
出版信息
Am J Respir Crit Care Med. 2013 Sep 1;188(5):530-7. doi: 10.1164/rccm.201304-0754PP.
Abstract
Derangements in normal cellular homeostasis at the protein level can cause or be the consequence of initiation and progression of pulmonary diseases related to genotype, infection, injury, smoking, toxin exposure, or neoplasm. We discuss one of the fundamental mechanisms of protein homeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease. The UPS effects selective degradation of ubiquitinated target proteins via ubiquitin ligase activity. Important pathobiological mechanisms relating to the UPS and lung disease have been the focus of research, with inappropriate cellular proteolysis now a validated therapeutic target. We review the contributions of this system in various lung diseases, and discuss the exciting area of UPS-targeting drug development for pulmonary disease.
摘要
蛋白质水平正常细胞内稳态的紊乱可导致与基因型、感染、损伤、吸烟、毒素暴露或肿瘤相关的肺部疾病的发生和进展，或者是其结果。我们讨论了蛋白质内稳态的基本机制之一，即泛素蛋白酶体系统 (UPS)，因为它与肺部疾病有关。UPS 通过泛素连接酶活性对泛素化靶蛋白进行选择性降解。UPS 与肺部疾病相关的重要病理生物学机制一直是研究的重点，现在不适当的细胞内蛋白水解已成为一个经过验证的治疗靶点。我们综述了该系统在各种肺部疾病中的作用，并讨论了 UPS 靶向药物开发这一肺部疾病治疗的令人兴奋的领域。
相似文献
1
The emerging role of the ubiquitin proteasome in pulmonary biology and disease.泛素蛋白酶体在肺生物学和疾病中的新兴作用。
Am J Respir Crit Care Med. 2013 Sep 1;188(5):530-7. doi: 10.1164/rccm.201304-0754PP.
2
Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review).通过含有 F-box 和其他模体的蛋白质增强泛素介导的蛋白水解系统（综述）。
Int J Oncol. 2010 Nov;37(5):1071-6. doi: 10.3892/ijo_00000758.
3
Roles of the ubiquitin-proteosome system in neurogenesis.泛素-蛋白酶体系统在神经发生中的作用。
Cell Cycle. 2010 Aug 15;9(16):3174-80. doi: 10.4161/cc.9.16.12551.
4
Ubiquitin, proteasome and parkin.泛素、蛋白酶体与帕金蛋白
Biochim Biophys Acta. 2004 Nov 29;1695(1-3):235-47. doi: 10.1016/j.bbamcr.2004.09.026.
5
[The ubiquitin-proteosome system: The deadly kiss].[泛素-蛋白酶体系统：致命之吻]
Medicina (B Aires). 2010;70(2):194-6.
6
New insights on the function of SCF ubiquitin E3 ligases in the lung.关于 SCF 泛素 E3 连接酶在肺部功能的新见解。
Cell Signal. 2013 Sep;25(9):1792-8. doi: 10.1016/j.cellsig.2013.05.003. Epub 2013 May 14.
7
[Impairment of the ubiquitin-proteasome system and neurodegeneration].[泛素-蛋白酶体系统损伤与神经退行性变]
Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Apr;26(2):67-73.
8
Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis.泛素-蛋白酶体系统针对三氧化二砷心脏毒性的激活涉及用于线粒体稳态的泛素连接酶帕金。
Toxicology. 2014 Aug 1;322:43-50. doi: 10.1016/j.tox.2014.04.008. Epub 2014 May 4.
9
[Cell cycle regulation by F-box protein Fbxw7].[F-box蛋白Fbxw7对细胞周期的调控]
Fukuoka Igaku Zasshi. 2009 Apr;100(4):87-94.
10
Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases.FBOX 泛素 E3 连接酶对正常和恶性造血的调控。
Trends Immunol. 2020 Dec;41(12):1128-1140. doi: 10.1016/j.it.2020.10.003. Epub 2020 Nov 4.
引用本文的文献
1
Interplay between proteasome function and inflammatory responses in e-cig vapor condensate-challenged lung epithelial cells.电子香烟蒸汽冷凝物刺激的肺上皮细胞中蛋白酶体功能与炎症反应的相互作用。
Arch Toxicol. 2023 Aug;97(8):2193-2208. doi: 10.1007/s00204-023-03504-5. Epub 2023 Jun 22.
2
IL-37-induced activation of glycogen synthase kinase 3β promotes IL-1R8/Sigirr phosphorylation, internalization, and degradation in lung epithelial cells.IL-37 诱导的糖原合酶激酶 3β 的激活促进肺上皮细胞中 IL-1R8/Sigirr 的磷酸化、内化和降解。
J Cell Physiol. 2021 Aug;236(8):5676-5685. doi: 10.1002/jcp.30253. Epub 2021 Jan 5.
3
The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome.去泛素化酶 STAMBP 通过 NLRP3 炎性小体调节细胞因子分泌。
Cell Signal. 2021 Mar;79:109859. doi: 10.1016/j.cellsig.2020.109859. Epub 2020 Nov 27.
4
A Plot TWIST in Pulmonary Arterial Hypertension.肺动脉高压中的一个意外转折。
Am J Respir Crit Care Med. 2020 Nov 1;202(9):1214-1216. doi: 10.1164/rccm.202006-2506ED.
5
The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome.去泛素化酶在急性肺损伤和急性呼吸窘迫综合征中的作用。
Int J Mol Sci. 2020 Jul 8;21(14):4842. doi: 10.3390/ijms21144842.
6
Associations between fungal and bacterial microbiota of airways and asthma endotypes.气道真菌和细菌微生物群与哮喘表型的相关性。
J Allergy Clin Immunol. 2019 Nov;144(5):1214-1227.e7. doi: 10.1016/j.jaci.2019.06.025. Epub 2019 Jul 3.
7
Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients.化疗诱导的周围神经病：来自全基因组关联研究的证据以及多发性骨髓瘤患者中的复制。
BMC Cancer. 2018 Aug 15;18(1):820. doi: 10.1186/s12885-018-4728-4.
8
Ubiquitin-proteasome signaling in lung injury.泛素-蛋白酶体信号通路在肺损伤中的作用。
Transl Res. 2018 Aug;198:29-39. doi: 10.1016/j.trsl.2018.04.003. Epub 2018 Apr 23.
9
The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis.泛素蛋白酶体系统作为系统性硬皮病的潜在治疗靶点。
Transl Res. 2018 Aug;198:17-28. doi: 10.1016/j.trsl.2018.03.003. Epub 2018 Mar 29.
10
Integrative genomics identifies new genes associated with severe COPD and emphysema.综合基因组学鉴定出与严重 COPD 和肺气肿相关的新基因。
Respir Res. 2018 Mar 22;19(1):46. doi: 10.1186/s12931-018-0744-9.
本文引用的文献
1
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.一种组合 F 框蛋白导向途径控制 TRAF 接头蛋白的稳定性，从而调节炎症反应。
Nat Immunol. 2013 May;14(5):470-9. doi: 10.1038/ni.2565. Epub 2013 Mar 31.
2
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.Miz1 通过抑制 C/EBP-δ 抑制炎症和急性肺损伤。
Nat Immunol. 2013 May;14(5):461-9. doi: 10.1038/ni.2566. Epub 2013 Mar 24.
3
Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?蛋白毒性与心脏功能障碍——心脏的阿尔茨海默病？
N Engl J Med. 2013 Jan 31;368(5):455-64. doi: 10.1056/NEJMra1106180.
4
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.E3 泛素连接酶中线 1 通过抑制蛋白磷酸酶 2A 活性促进过敏原和鼻病毒引起的哮喘。
Nat Med. 2013 Feb;19(2):232-7. doi: 10.1038/nm.3049. Epub 2013 Jan 20.
5
Linear ubiquitination: a newly discovered regulator of cell signalling.线性泛素化：一种新发现的细胞信号调节因子。
Trends Biochem Sci. 2013 Feb;38(2):94-102. doi: 10.1016/j.tibs.2012.11.007. Epub 2013 Jan 17.
6
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.遗传性 HOIL-1 和 LUBAC 缺陷导致的人类免疫缺陷、自身炎症和淀粉样多聚糖沉积症。
Nat Immunol. 2012 Dec;13(12):1178-86. doi: 10.1038/ni.2457. Epub 2012 Oct 28.
7
Acute cigarette smoke exposure impairs proteasome function in the lung.急性香烟烟雾暴露会损害肺部的蛋白酶体功能。
Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1;303(9):L814-23. doi: 10.1152/ajplung.00128.2012. Epub 2012 Sep 7.
8
Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/ GMMG-HD4 trial.硼替佐米诱导和维持治疗新诊断多发性骨髓瘤患者：随机 III 期 HOVON-65/GMMG-HD4 试验结果。
J Clin Oncol. 2012 Aug 20;30(24):2946-55. doi: 10.1200/JCO.2011.39.6820. Epub 2012 Jul 16.
9
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.FBXL19 介导的 F-box 蛋白泛素化和 IL-33 受体的降解限制了肺部炎症。
Nat Immunol. 2012 Jun 3;13(7):651-8. doi: 10.1038/ni.2341.
10
Ubiquitination and proteolysis in acute lung injury.泛素化和蛋白水解在急性肺损伤中的作用。
Chest. 2012 Mar;141(3):763-771. doi: 10.1378/chest.11-1660.
Zotero 插件