Transplant and Oncology Infectious Diseases Program, Johns Hopkins University School of Medicine, 1830 Baltimore, MD 21205, USA.
Infect Dis Clin North Am. 2013 Jun;27(2):343-58. doi: 10.1016/j.idc.2013.02.006. Epub 2013 Apr 17.
Infections with multidrug-resistant organisms are a growing problem in lung transplant recipients. Carriage of drug-resistant bacteria and fungi before transplantation is an important risk factor for such infections. In that regard Pseudomonas aeruginosa and species of Burkholderia, Acinetobacter, non-tuberculous mycobacteria and Scedosporium are particularly important. An understanding of the impact of these organisms is essential to the evaluation of lung transplant candidates. The microbiology, epidemiology, clinical manifestations, and approach to these pathogens before transplant are reviewed in this article.
肺移植受者中，多重耐药菌感染是一个日益严重的问题。移植前携带耐药菌和真菌是此类感染的一个重要危险因素。在这方面，铜绿假单胞菌和伯克霍尔德菌属、不动杆菌属、非结核分枝杆菌和枝顶孢属的物种尤其重要。了解这些病原体的影响对于评估肺移植候选者至关重要。本文综述了这些病原体在移植前的微生物学、流行病学、临床表现和处理方法。
