Cogo A, Ling E, Sturk A, ten Cate J W, Prandoni P
Clinica Medica II, Università degli Studi di Padova.
Ric Clin Lab. 1990 Apr-Jun;20(2):113-7. doi: 10.1007/BF02877557.
An important plasminogen activator-inhibitor (PAI-1) is present in plasma and concentrated in alpha-granules of platelets. PAI-1 is released during platelet stimulation in vitro. It is presently unknown to what extent the treatment with acetylsalicylic acid (ASA) inhibits platelet PAI-1 release and if release inhibition has an effect on plasma PAI-1 levels. We therefore investigated by a double-blind placebo-controlled crossover study the effects of oral ASA (500 mg/day for 3 days) on platelet PAI-1 release and on plasma PAI-1 levels of healthy male volunteers. The PAI-1 release from platelets stimulated by arachidonic acid and collagen was significantly reduced by ASA: from average values of 88 and 80% to 14 and 17%, respectively (p less than 0.01). However, plasma PAI-1 levels were not modified by this treatment. We can conclude that platelet PAI-1 release does not play a role in modulating the plasma PAI-1 levels in healthy volunteers.
一种重要的纤溶酶原激活物抑制剂（PAI - 1）存在于血浆中，并集中在血小板的α颗粒中。PAI - 1在体外血小板刺激过程中释放。目前尚不清楚乙酰水杨酸（ASA）治疗在多大程度上抑制血小板PAI - 1的释放，以及释放抑制是否对血浆PAI - 1水平有影响。因此，我们通过一项双盲安慰剂对照交叉研究，调查了口服ASA（500毫克/天，共3天）对健康男性志愿者血小板PAI - 1释放及血浆PAI - 1水平的影响。ASA显著降低了由花生四烯酸和胶原蛋白刺激引起的血小板PAI - 1释放：分别从平均值88%和80%降至14%和17%（p小于0.01）。然而，这种治疗并未改变血浆PAI - 1水平。我们可以得出结论，在健康志愿者中，血小板PAI - 1的释放在调节血浆PAI - 1水平方面不起作用。
