用于分析人中性粒细胞弹性蛋白酶的高特异性、多分支荧光报告分子。
Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase.
机构信息
EaStChem, School of Chemistry, University of Edinburgh, West Mains Road, EH9 3JJ, Edinburgh, UK.
出版信息
Org Biomol Chem. 2013 Jul 14;11(26):4414-8. doi: 10.1039/c3ob40212f. Epub 2013 May 28.
PMID:23715090
Abstract
Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.
摘要
人中性粒细胞弹性蛋白酶（HNE）是一种丝氨酸蛋白酶，与急性和慢性炎症性疾病的发病机制有关。本文合成了一系列内部猝灭的单荧光报告物，可快速、高度特异性和敏感地分析 HNE 活性及其与密切相关的蛋白酶。
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