HHMI/Children's Hospital Boston, Boston, MA 02115, USA.
Development. 2013 Jun;140(12):2463-7. doi: 10.1242/dev.083147.
Hematopoiesis - the process by which blood cells are formed - has been studied intensely for over a century using a variety of model systems. There is conservation of the overall hematopoietic process between vertebrates, although some differences do exist. Over the last decade, the zebrafish has come to the forefront as a new model in hematopoiesis research, as it allows the use of large-scale genetics, chemical screens and transgenics. This comparative approach to understanding hematopoiesis has led to fundamental knowledge about the process and to the development of new therapies for disease. Here, we provide a broad overview of vertebrate hematopoiesis. We also highlight the benefits of using zebrafish as a model.
造血 - 血细胞形成的过程 - 已经使用各种模型系统进行了一个多世纪的深入研究。尽管存在一些差异，但脊椎动物之间的整体造血过程是保守的。在过去的十年中，斑马鱼作为一种新的造血研究模型脱颖而出，因为它允许使用大规模的遗传学、化学筛选和转基因技术。这种比较方法来理解造血导致了对该过程的基本认识，并为疾病开发了新的治疗方法。在这里，我们提供了一个关于脊椎动物造血的广泛概述。我们还强调了使用斑马鱼作为模型的好处。
