Bu4NI 催化的 sp3 C-H 键与杂原子相邻的脱羧酰氧基化反应与 α-氧代羧酸。
Bu4NI-catalyzed decarboxylative acyloxylation of an sp3 C-H bond adjacent to a heteroatom with α-oxocarboxylic acids.
机构信息
Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China.
出版信息
Org Biomol Chem. 2013 Jul 14;11(26):4308-11. doi: 10.1039/c3ob40748a. Epub 2013 May 29.
PMID:23715588
Abstract
A novel metal-free decarboxylative acyloxylation of an sp(3) C-H bond in formamides and ethers has been explored. A variety of N-acyloxymethylamides and α-acyloxy ethers could be easily synthesized by this method. Preliminary mechanistic studies have shown that the reaction proceeded via a radical process.
摘要
一种新型的无金属脱羧酰氧基化反应，可在甲酰胺和醚类化合物的 sp(3) C-H 键上进行。该方法可以很容易地合成各种 N-酰氧基甲基酰胺和α-烷氧基醚。初步的机理研究表明，该反应是通过自由基过程进行的。
Zotero 插件