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暴露于广泛的环境毒物与儿童认知发育和行为问题。

Exposure to widespread environmental toxicants and children's cognitive development and behavioral problems.

机构信息

Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.

出版信息

Int J Occup Med Environ Health. 2013 Apr;26(2):185-204. doi: 10.2478/s13382-013-0099-x. Epub 2013 May 28.

Abstract

Nowadays a special attention is focused on prenatal and childhood exposures to a variety of contaminants in the environment, especially toxicants widely present in the environment and their impact on children's health and neurodevelopment. This article aims at evaluating the impact of exposure to several widespread toxicants including: polycyclic aromatic hydrocarbons (PAHs), phthalates, bisphenol A, brominated flame retardants and gas cooking on children's cognitive development and behavioral problems by reviewing most recent published literature. Epidemiological studies focusing on exposure to widespread toxicants and children's development for the last eleven years were identified by a search of the PubMed, Medline, Ebsco and Toxnet literature bases. The combination of following key words was used: 1) referring to the exposure: pregnancy, prenatal exposure, postnatal exposure, gas cooking, exposure to phthalates, bisphenol A, brominated flame retardants, PAHs and 2) referring to outcome: neurodevelopment, neurobehavior, psychomotor development, behavioral problems, cognitive development, mental health, school achievements, learning abilities. The results from the presented studies suggest that there are strong and rather consistent indications that the developing nervous system is particularly vulnerable to insult from low levels of exposure to widespread environmental contaminants such as: phthalates, bisphenol A, brominated flame retardants, polycyclic aromatic hydrocarbons, gas cooking. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.

摘要

如今,人们特别关注产前和儿童时期暴露于环境中的各种污染物,尤其是广泛存在于环境中的有毒物质及其对儿童健康和神经发育的影响。本文旨在通过回顾最新发表的文献,评估接触多种广泛存在的有毒物质(包括多环芳烃、邻苯二甲酸酯、双酚 A、溴化阻燃剂和燃气烹饪)对儿童认知发展和行为问题的影响。通过在 PubMed、Medline、Ebsco 和 Toxnet 文献数据库中搜索,确定了过去十一年中关注广泛存在的有毒物质暴露与儿童发育的流行病学研究。使用了以下关键词的组合:1)关于暴露:妊娠、产前暴露、产后暴露、燃气烹饪、邻苯二甲酸酯暴露、双酚 A、溴化阻燃剂、多环芳烃和 2)关于结果:神经发育、神经行为、精神运动发育、行为问题、认知发展、心理健康、学业成绩、学习能力。呈现的研究结果表明,有强有力且相当一致的证据表明,发育中的神经系统特别容易受到广泛环境污染物(如邻苯二甲酸酯、双酚 A、溴化阻燃剂、多环芳烃、燃气烹饪)低水平暴露的伤害。考虑到所建议的健康影响,迫切需要更多的流行病学数据,同时必须实施预防政策。

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