Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.
INSPECT-LB:, Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie, Beirut, Lebanon.
Environ Sci Pollut Res Int. 2019 May;26(14):14373-14381. doi: 10.1007/s11356-019-04797-9. Epub 2019 Mar 13.
To evaluate the relation between caregiver exposure to toxics during pregnancy and childhood and the child's cognitive function in Lebanese children. This was a cross-sectional study conducted on Lebanese students in public and private schools from November 2017 to May 2018, enrolling 464 children. A first linear regression, taking the Cattell total score as the dependent variable and taking sociodemographic characteristics and the family history of the child as independent variables, showed that higher age (Beta = 1.65) was significantly associated with higher cognition, whereas a history of eczema in any of the parents (Beta = -7.32) was significantly associated with lower cognition in the child. A second linear regression, taking the Cattell total score as the dependent variable and taking sociodemographic characteristics and the family history of the child, and the exposure to toxics as independent variables, showed that maternal alcohol intake during pregnancy (Beta = -1.07) and detergent mixing (Beta = -1.48) were significantly associated with lower cognition in the child. A third linear regression, taking the Cattell total score as the dependent variable and taking sociodemographic characteristics and the family history of the child, the exposure to toxics and the diseases in the child as independent variables, showed that maternal alcohol intake during pregnancy (Beta = -1.07) and detergent mixing (Beta = -1.45) were significantly associated with lower cognition in the child, whereas a history of eczema in the child before the age of 2 years (Beta = 8.72) was significantly associated with higher cognition in the child. This study is the first to examine the association of a child's prenatal exposure and their exposure during childhood to environmental toxicants with their cognitive function in Lebanon. We consider this study to be important as it shows the possible effect of cleaning products mixing and maternal alcohol consumption on cognitive functions among children in Lebanon.
为了评估黎巴嫩儿童的看护者在怀孕期间和儿童期接触有毒物质与儿童认知功能之间的关系。这是一项横断面研究，于 2017 年 11 月至 2018 年 5 月期间在黎巴嫩公立和私立学校的学生中进行，共纳入 464 名儿童。第一次线性回归，以 Cattell 总分为因变量，以社会人口特征和儿童的家族史为自变量，结果显示年龄较大（Beta=1.65）与认知能力较高显著相关，而父母任何一方有湿疹史（Beta=-7.32）与儿童认知能力较低显著相关。第二次线性回归，以 Cattell 总分为因变量，以社会人口特征和儿童的家族史、儿童的接触有毒物质情况为自变量，结果显示母亲在怀孕期间饮酒（Beta=-1.07）和混合洗涤剂（Beta=-1.48）与儿童认知能力较低显著相关。第三次线性回归，以 Cattell 总分为因变量，以社会人口特征和儿童的家族史、儿童的接触有毒物质情况和儿童的疾病为自变量，结果显示母亲在怀孕期间饮酒（Beta=-1.07）和混合洗涤剂（Beta=-1.45）与儿童认知能力较低显著相关，而儿童在 2 岁前有湿疹史（Beta=8.72）与儿童认知能力较高显著相关。本研究首次探讨了黎巴嫩儿童在胎儿期和儿童期接触环境有毒物质与其认知功能之间的关系。我们认为这项研究很重要，因为它表明了清洁产品混合和母亲饮酒可能对黎巴嫩儿童的认知功能产生影响。
