Li Hongmei, Du Zhirong, Zhang Lin, Wu Tong, Deng Zhihui, Li Jingping, Cong Mingyu, Liu Jicheng, Qiu Changchun
Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
Angiology. 2014 Aug;65(7):614-9. doi: 10.1177/0003319713491309. Epub 2013 May 28.
Gene polymorphisms of the renin-angiotensin system are involved in the pathophysiology of hypertension. We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population. There were significant differences in the distribution of genotypes and allele frequencies at C4072T between the patients and the controls (both P < .01); patients with CC genotype had a higher risk of hypertension (odds ratio = 1.7, 95% confidence interval 1.4-2.1). The distribution of genotypes at A-6G was significantly different between patients and controls (P < .05). No other significant differences in genotypes or frequencies were observed. No association was observed between the haplotypes of AGT and hypertension. The AGT-6A and 4072C alleles are associated with susceptibility to hypertension in this population.
肾素 - 血管紧张素系统的基因多态性参与高血压的病理生理过程。我们采用聚合酶链反应 - 限制性片段长度多态性方法，对652例患者和780例对照者的血管紧张素原（AGT）基因的4种多态性A - 20C（rs5050）、A - 6G（rs5051）、C3889T（rs4762）和C4072T（rs699）进行基因分型，以研究中国北方汉族人群中AGT与高血压的相关性。患者与对照者在C4072T位点的基因型和等位基因频率分布存在显著差异（均P <.01）；CC基因型患者患高血压的风险更高（比值比 = 1.7，95%置信区间1.4 - 2.1）。患者与对照者在A - 6G位点的基因型分布也存在显著差异（P <.05）。未观察到其他基因型或频率的显著差异。未观察到AGT单倍型与高血压之间的关联。在该人群中，AGT - 6A和4072C等位基因与高血压易感性相关。
